BORC-ARL8-HOPS ensemble is required for lysosomal cholesterol egress through NPC2-Reference-Cited by-同舟云学术

BORC-ARL8-HOPS ensemble is required for lysosomal cholesterol egress through NPC2

Published:2022-08-01 Issue:9 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Anderson Jacob¹²,Walker Gerard³,Pu Jing¹²^ORCID

Affiliation:

1. Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131

2. Autophagy, Inflammation, and Metabolism Center of Biomedical Research Excellence, University of New Mexico, Albuquerque, NM 87131

3. Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892

Abstract

BORC-ARL8-HOPS ensemble is required for egress of cholesterol from lysosomes; deficiency of cholesterol egress causes reduced cholesteryl esters in lipid droplets. BORC-ARL8-HOPS depletion enhances secretion of the lysosomal cholesterol transporter NPC2, causes cellular NPC2 mislocalization, and promotes degradation of the NPC2 sorting receptor, CI-MPR.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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