Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function-Reference-Cited by-同舟云学术

Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function

Published:2021-10-01 Issue:20 Volume:32 Page:ar10
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Denarier E.¹,Ecklund K. H.²,Berthier G.¹,Favier A.¹,O’Toole E. T.³,Gory-Fauré S.¹,De Macedo L.¹,Delphin C.¹,Andrieux A.¹,Markus S. M.²,Boscheron C.¹

Affiliation:

1. Université Grenoble Alpes, Commissariat à l’énergie atomique et aux énergies alternatives, Centre national de la recherche scientifique, Grenoble institut des neurosciences, Institut de biologie structurale, Institut national de la santé et de la recherche médicale, lnstitut de recherche interdisciplinaire de Grenoble, F-38000 Grenoble, France

2. Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523

3. Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Boulder, CO 80302

Abstract

The authors of this study employ budding yeast to model a disease-correlated tubulin mutation to determine how it leads to microtubule dysfunction. They find that the mutation leads to alterations in microtubule dynamics, tubulin isotype usage, and a spindle positioning defect that is due to disrupted microtubule-binding by a dynein regulator.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference110 articles.

1. Microtubule Interactions with the Cell Cortex Causing Nuclear Movements in Saccharomyces cerevisiae

2. Genome-wide Analysis Reveals Novel and Discrete Functions for Tubulin Carboxy-Terminal Tails

3. High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

4. Suppression of nuclear oscillations in Saccharomyces cerevisiae expressing Glu tubulin

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