Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1-Reference-Cited by-同舟云学术

Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1

Published:2020-11-01 Issue:23 Volume:31 Page:2583-2596
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Boyle John M.¹,Hennick Kelsey M.¹,Regalado Samuel G.¹,Vogan Jacob M.¹,Zhang Xiaozhu¹,Collins Kathleen¹,Hockemeyer Dirk¹²³

Affiliation:

1. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720

2. Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720

3. Chan Zuckerberg Biohub, San Francisco, CA 94158

Abstract

To better understand telomere length set point control in human stem cells, we generated knockout stem cell lines for TPP1 and contrasted their phenotypes with those of homozygous TPP1 L104A mutant stem cells. This comparison reveals that TPP1 L104A is not a hypomorphic allele but formally establishes TPP1 L104 as a dissociation of function mutant.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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1. Telomeres and Aging

2. Understanding telomere diseases through analysis of patient-derived iPS cells

3. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

4. Widespread Translational Remodeling during Human Neuronal Differentiation

5. Telomere Length Dynamics in Telomerase-Positive Immortal Human Cell Populations

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