AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells-Reference-Cited by-同舟云学术

AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells

Published:2020-01-15 Issue:2 Volume:31 Page:118-130
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Brunner Patrizia¹²,Hastar Nurcan¹³,Kaehler Christian¹,Burdzinski Wiktor¹,Jatzlau Jerome¹³,Knaus Petra¹³

Affiliation:

1. Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany

2. Berlin School of Integrative Oncology, Charité–Universitätsmedizin Berlin, 13353 Berlin, Germany

3. Berlin-Brandenburg School for Regenerative Therapies, Charité–Universitätsmedizin Berlin, 13353 Berlin, Germany

Abstract

We found that the tight-junction protein angiomotin (AMOT130) interacts with the BMP receptor BMPR2 and thereby supports BMP/SMAD signaling exclusively at the apical side of polarized epithelial and endothelial cells. BMP-mediated internalization of AMOT discerns BMPs as novel regulators of AMOT function.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference64 articles.

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3. BlobFinder, a tool for fluorescence microscopy image cytometry

4. Differential regulation of translation and endocytosis of alternatively spliced forms of the type II bone morphogenetic protein (BMP) receptor

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