The myosin light-chain kinase MLCK-1 relocalizes duringCaenorhabditis elegansovulation to promote actomyosin bundle assembly and drive contraction-Reference-Cited by-同舟云学术

The myosin light-chain kinase MLCK-1 relocalizes duringCaenorhabditis elegansovulation to promote actomyosin bundle assembly and drive contraction

Published:2018-08-08 Issue:16 Volume:29 Page:1975-1991
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Kelley Charlotte A.¹,Wirshing Alison C. E.¹,Zaidel-Bar Ronen²,Cram Erin J.¹

Affiliation:

1. Department of Biology, Northeastern University, Boston, MA 02115

2. Department of Cell and Developmental Biology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel

Abstract

We identify the Caenorhabditis elegans myosin light-chain kinase, MLCK-1, required for contraction of spermathecae. During contraction, MLCK-1 moves from the apical cell boundaries to the basal actomyosin bundles, where it stabilizes myosin downstream of calcium signaling. MLCK and ROCK act in distinct subsets of cells to coordinate the timing of contraction.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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