Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages-Reference-Cited by-同舟云学术

Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages

Published:2015-03 Issue:5 Volume:26 Page:952-965
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Yeo Jeremy C.¹,Wall Adam A.¹,Luo Lin¹,Stow Jennifer L.¹

Affiliation:

1. Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia

Abstract

Rab31 recruits APPL2 to regulate phagocytic cup closure and FcγR signaling pathways via production of PI(3,4,5)P3 in macrophages. APPL2 is poised to activate macrophages and act as a counterpoint to APPL1 in FcγR-mediated PI3K/Akt signaling. New locations and roles are found for Rab31 and APPL2 by which they contribute to innate immune functions.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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