The endoplasmic reticulum contributes to lysosomal tubulation/sorting driven by LRRK2-Reference-Cited by-同舟云学术

The endoplasmic reticulum contributes to lysosomal tubulation/sorting driven by LRRK2

Published:2022-11-01 Issue:13 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Bonet-Ponce Luis¹^ORCID,Cookson Mark R.¹^ORCID

Affiliation:

1. Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892

Abstract

A role of the ER as a new regulator of lysosomal sorting is reported. Using advanced microscopy, it is reported that ER tubules colocalize with lysosomal tubules in the sorting site. Mechanistically, it is shown that reduction of the number of ER tubules leads to a significant decrease in lysosomal sorting.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference60 articles.

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