Viral protein X unlocks the nuclear pore complex through a human Nup153-dependent pathway to promote nuclear translocation of the lentiviral genome-Reference-Cited by-同舟云学术

Viral protein X unlocks the nuclear pore complex through a human Nup153-dependent pathway to promote nuclear translocation of the lentiviral genome

Published:2020-02-15 Issue:4 Volume:31 Page:304-317
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Singh Satya Prakash¹,Raja Sebastian¹,Mahalingam Sundarasamy¹²

Affiliation:

1. Laboratory of Molecular Cell Biology, Indian Institute of Technology-Madras, Chennai 600 036, India

2. National Cancer Tissue Biobank, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology-Madras, Chennai 600 036, India

Abstract

MAPK/ERK-2–mediated phosphorylation regulates HIV-2/SIV Vpx interaction with human Nup153, which is critical for altering the nuclear membrane assembly for efficient transport of the lentiviral genome into the nucleus of nondividing target cells.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference75 articles.

1. HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

2. The molecular architecture of the nuclear pore complex

3. Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells

4. Conserved amino acids of the human immunodeficiency virus type 2 Vpx nuclear localization signal are critical for nuclear targeting of the viral preintegration complex in non-dividing cells

5. A nucleoprotein complex mediates the integration of retroviral DNA.

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