Phosphatidylinositol 4-kinase III beta regulates cell shape, migration, and focal adhesion number-Reference-Cited by-同舟云学术

Phosphatidylinositol 4-kinase III beta regulates cell shape, migration, and focal adhesion number

Published:2020-08-01 Issue:17 Volume:31 Page:1904-1916
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Bilodeau Patricia¹,Jacobsen Daniel¹,Law-Vinh Denise¹,Lee Jonathan M.¹

Affiliation:

1. Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada

Abstract

This work describes a role for the lipid phosphatidylinositol 4-phosphate (PI4P) and lipid kinase phosphatidylinositol 4-kinase III beta (PI4KIIIβ) in cell motility, cell shape, and focal adhesion (FA) formation. During fibroblast migration, PI4P vesicles move to the leading edge and fuse with FA there. Deletion of PI4KIIIB impairs fibroblast migration, increases the number of FA, and alters cell shape.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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