The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A-Reference-Cited by-同舟云学术

The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A

Published:2020-04-15 Issue:9 Volume:31 Page:963-979
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Mattera Rafael¹,Williamson Chad D.¹,Ren Xuefeng²,Bonifacino Juan S.¹

Affiliation:

1. Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892

2. Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720

Abstract

In this study, we identify the dynein–dynactin adaptor FTS-Hook-FHIP (FHF) complex as an accessory factor for the TGN-associated adaptor protein 4 (AP-4) coat. We show that FHF is required for distribution of AP-4 and its cargo ATG9A to the perinuclear area, highlighting a novel mechanism for coupling of transport vesicles to microtubule motors.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference89 articles.

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