Growth disadvantage associated with centrosome amplification drives population-level centriole number homeostasis-Reference-Cited by-同舟云学术

Growth disadvantage associated with centrosome amplification drives population-level centriole number homeostasis

Published:2020-11-15 Issue:24 Volume:31 Page:2646-2656
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Sala Roberta¹,Farrell KC¹,Stearns Tim¹²

Affiliation:

1. Department of Biology, Stanford University, Stanford, CA 94305

2. Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305

Abstract

The centriole duplication cycle normally maintains number at two centrioles per G1 cell. However, some circumstances can result in an aberrant increase in centriole number. Cells with extra centrioles display extended cell cycle arrest, longer interphase durations, and death, which result in a proliferative disadvantage relative to normal cells.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference42 articles.

1. Centrosome Amplification Can Initiate Tumorigenesis in Flies

2. Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells

3. SAK/PLK4 Is Required for Centriole Duplication and Flagella Development

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