Biophysics at the coffee shop: lessons learned working with George Oster

Author:

Igoshin Oleg A.1,Chen Jing2,Xing Jianhua3,Liu Jian4,Elston Timothy C.5,Grabe Michael6,Kim Kenneth S.7,Nirody Jasmine A.8,Rangamani Padmini9,Sun Sean X.10,Wang Hongyun11,Wolgemuth Charles12

Affiliation:

1. Departments of Bioengineering, Biosciences, and Chemistry and Center for Theoretical Biological Physics, Rice University, Houston, TX 77005

2. Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061

3. Department of Computational and Systems Biology and UPMC-Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261

4. Department of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205

5. Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

6. Cardiovascular Research Institute, School of Pharmacy, University of California, San Francisco, San Francisco, CA 94158

7. Lawrence Livermore National Laboratory, Livermore, CA 94550

8. Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10065

9. Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093

10. Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218

11. Department of Applied Mathematics and Statistics, University of California, Santa Cruz, Santa Cruz, CA 95064

12. Department of Physics and Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721

Abstract

Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry. George Oster stood out as a pioneer of this paradigm shift from descriptive to quantitative biology not only through his numerous research accomplishments, but also through the many students and postdocs he mentored over his long career. Those of us fortunate enough to have worked with George agree that his sharp intellect, physical intuition, and passion for scientific inquiry not only inspired us as scientists but also greatly influenced the way we conduct research. We would like to share a few important lessons we learned from George in honor of his memory and with the hope that they may inspire future generations of scientists.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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