Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein-Reference-Cited by-同舟云学术

Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein

Published:2021-03-01 Issue:5 Volume:32 Page:376-390
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Nouri-Nejad Daniel¹,O’Donnell Brooke L.¹,Patil Chetan S.²³,Sanchez-Pupo Rafael E.¹,Johnston Danielle¹,Sayedyahossein Samar¹,Jurcic Kristina⁴,Lau Rebecca¹,Gyenis Laszlo⁴,Litchfield David W.⁴⁵,Jackson Michael F.²³,Gloor Gregory B.⁴,Penuela Silvia¹⁵

Affiliation:

1. Department of Anatomy and Cell Biology, Western University, London, ON N6A 5C1, Canada

2. Department of Pharmacology & Therapeutics, University of Manitoba, Winnipeg, MB R3E 0T6, Canada

3. Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, MB R3E 0Z3, Canada

4. Department of Biochemistry, Western University, London, ON N6A 5C1, Canada

5. Department of Oncology, Division of Experimental Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada

Abstract

In this study, we discovered the first mutation in a phosphorylation site of pannexin 1 (PANX1) that affects phosphorylation, glycosylation, and trafficking of PANX1 channels in a melanoma patient tumor. We also reported on the ancestral allele of PANX1 that is the most representative variant within human populations.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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4. Functional outcome of pannexin-deficient mice after cerebral ischemia

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