Polarized human cholangiocytes release distinct populations of apical and basolateral small extracellular vesicles

Abstract

Human cholangiocytes, epithelial cells that line the bile ducts, were cultured as a model with which to study polarized small extracellular vesicle (sEV) communication. These cells release distinct sEV pools to mediate communication via their apical and basolateral domains. Furthermore, defective ESCRT function may contribute to disease states through altered sEV signaling.