Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response

Abstract

Increasing evidence suggests that lipid homeostasis is critical for protein quality control. Very-long-chain fatty acids (VLCFA) are rare and poorly understood species. Here, it is shown that dysregulation of VLCFA metabolism causes increased membrane saturation, endoplasmic reticulum stress, and unfolded protein response induction.