Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit-Reference-Cited by-同舟云学术

Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit

Published:2020-05-15 Issue:11 Volume:31 Page:1112-1123
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Matta Srujan Kumar¹,Kumar Abhishek¹,D’Silva Patrick¹

Affiliation:

1. Department of Biochemistry, New Biological Sciences Building, Indian Institute of Science, Bangalore-560012, India

Abstract

Mgr2 regulates the gating behavior of the TIM23 complex and mgr2∆ and causes aberrations in mitochondrial dynamics. Here, we show that Mgr2 directly associates with channel-forming Tim23. Additionally, the Mgr2 transmembrane region plays a crucial role in coupling the TIM23 complex with OXPHOS machinery and thus regulates mitochondrial protein import and dynamics.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference77 articles.

1. The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes

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3. Structure of the mitochondrial import gate reveals distinct preprotein paths

4. Molecular Basis of the Dynamic Structure of the TIM23 Complex in the Mitochondrial Intermembrane Space

5. Mitochondrial protein-import machinery: correlating structure with function

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