Multisite phosphorylation determines the formation of Ska–Ndc80 macro-complexes that are essential for chromosome segregation during mitosis-Reference-Cited by-同舟云学术

Multisite phosphorylation determines the formation of Ska–Ndc80 macro-complexes that are essential for chromosome segregation during mitosis

Published:2020-08-01 Issue:17 Volume:31 Page:1892-1903
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Zhang Qian¹,Hu Liqiao²,Chen Yujue¹,Tian Wei²,Liu Hong¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, Tulane University Health Science Center, New Orleans, LA 70112

2. Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

Abstract

Ska loading to kinetochore is essential for chromosome segregation during mitosis. Here we show that multisite Cdk1 phosphorylation enables the formation of Ska-Ndc80 macro-complexes, thus loading Ska to kinetochores. This process is facilitated by spindle microtubules.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference41 articles.

1. Structural basis for microtubule recognition by the human kinetochore Ska complex

2. Ska3 Ensures Timely Mitotic Progression by Interacting Directly With Microtubules and Ska1 Microtubule Binding Domain

3. Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment

4. Resonance assignments of the microtubule-binding domain of the C. elegans spindle and kinetochore-associated protein 1

5. Aurora B controls kinetochore–microtubule attachments by inhibiting Ska complex–KMN network interaction

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