Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length-Reference-Cited by-同舟云学术

Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length

Published:2019-12-15 Issue:26 Volume:30 Page:3136-3150
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Bizarro Jonathan¹,Bhardwaj Amit²,Smith Susan²,Meier U. Thomas¹^ORCID

Affiliation:

1. Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461

2. Department of Pathology, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016

Abstract

Two major components of nuclear Cajal bodies (CBs) are small CB-specific scaRNPs and their targets, spliceosomal snRNPs. The intrinsically disordered phosphoprotein Nopp140 is required to recruit and retain all scaRNPs including telomerase in CBs. Knockdown of Nopp140 releases all scaRNPs, but not snRNPs, causing gradual telomere lengthening.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference65 articles.

1. Microinjection of Anti-coilin Antibodies Affects the Structure of Coiled Bodies

2. Human Nopp140, Which Interacts with RNA Polymerase I: Implications for rRNA Gene Transcription and Nucleolar Structural Organization

3. An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

4. Human Telomerase RNA Accumulation in Cajal Bodies Facilitates Telomerase Recruitment to Telomeres and Telomere Elongation

5. Telomere length homeostasis requires that telomerase levels are limiting

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