The effect of marrow secretome and culture environment on the rate of metastatic breast cancer cell migration in two and three dimensions-Reference-Cited by-同舟云学术

The effect of marrow secretome and culture environment on the rate of metastatic breast cancer cell migration in two and three dimensions

Published:2021-05-01 Issue:10 Volume:32 Page:1009-1019
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Curtis Kimberly J.¹²,Mai Christine³,Martin Hannah³,Oberman Alyssa G.¹²,Alderfer Laura¹²,Romero-Moreno Ricardo⁴²,Walsh Mark⁵⁶,Mitros Stephen F.⁶,Thomas Scott G.⁵,Dynako Joseph A.⁵,Zimmer David I.⁵,McNamara Laoise M.⁷,Littlepage Laurie E.⁴²,Niebur Glen L.¹³²

Affiliation:

1. Bioengineering Graduate Program, University of Notre Dame, IN 46556

2. Harper Cancer Research Institute, University of Notre Dame, IN 46556

3. Department of Aerospace and Mechanical Engineering, University of Notre Dame, IN 46556

4. Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556

5. Indiana University School of Medicine, South Bend Campus, Notre Dame, IN 46556

6. Beacon Medical Group, Trauma and Surgical Services, South Bend, IN, 46601

7. Mechanobiology and Medical Devices Research Group, Biomedical Engineering, College of Engineering and Informatics, National University of Ireland, Galway, Ireland H91 CF50

Abstract

We show that MDA-MB-231 cells migrate to trabecular bone explants with intact marrow faster than to bone devoid of marrow or devitalized bone. Cells also migrated toward bone with intact marrow when cultured in three-dimensional gelatin constructs. They were more likely to migrate in stiff versus soft substrates, but their speed was not affected by stiffness.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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