Microtubule nucleation promoters Mto1 and Mto2 regulate cytokinesis in fission yeast

Author:

Dundon Samantha E. R.1,Pollard Thomas D.123

Affiliation:

1. Departments of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8103

2. Departments of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8103

3. Department of Cell Biology, Yale University, New Haven, CT 06520-8103

Abstract

Dundon and Pollard show that compromising the Mto1 or Mto2 regulators of the fission yeast γ-tubulin complex reduces or eliminates astral microtubules, exaggerates the effects of a D277N substitution in β-glucan synthase 1 (Cps1/Bgs1) on the rate of cytokinetic furrow formation, and increases Rho1-GTP at the cleavage site.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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