The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy

Author:

Granada Adrián E.12,Jiménez Alba2,Stewart-Ornstein Jacob23,Blüthgen Nils1456,Reber Simone17,Jambhekar Ashwini2,Lahav Galit2

Affiliation:

1. IRI Life Sciences, Humboldt University Berlin, 10115 Berlin, Germany

2. Department of Systems Biology, Harvard Medical School, Boston, MA 02115

3. Department of Computational and Systems Biology, University of Pittsburgh Medical School, Pittsburgh, PA 15260

4. Institute of Pathology, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany

5. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 ­Heidelberg, Germany

6. Berlin Institute of Health (BIH), 10178 Berlin, Germany

7. University of Applied Sciences Berlin, 13353 Berlin, Germany

Abstract

DNA-damaging chemotherapy often leaves residual tumor cells. Combining single-cell long-term live imaging with information theory, we found an unexpected effect: highly proliferative cells were more likely to arrest than to die, whereas more slowly proliferating cells showed a higher probability of death.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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