Strain-induced mechanoresponse depends on cell contractility and BAG3-mediated autophagy-Reference-Cited by-同舟云学术

Strain-induced mechanoresponse depends on cell contractility and BAG3-mediated autophagy

Published:2021-10-01 Issue:20 Volume:32 Page:ar9
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Lövenich Lukas¹,Dreissen Georg¹,Hoffmann Christina¹,Konrad Jens¹,Springer Ronald¹,Höhfeld Jörg²,Merkel Rudolf¹,Hoffmann Bernd¹

Affiliation:

1. Mechanobiology, Institute of Biological Information Processing, Forschungszentrum Jülich, 52428 Jülich, Germany

2. Institute for Cell Biology, University of Bonn, 53121 Bonn, Germany

Abstract

The mechanosensitivity of mammalian cells and protein degradation via autophagy are two essential regulatory cell mechanisms. The close interplay between these two mechanisms is characterized in detail and proves a strong bidirectional cross-talk between BAG3-mediated chaperone-assisted selective autophagy and mechanosensitivity.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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