PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis-Reference-Cited by-同舟云学术

PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

Published:2021-11-01 Issue:21 Volume:32 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Sluysmans Sophie¹,Méan Isabelle¹,Xiao Tong²,Boukhatemi Amina¹,Ferreira Flavio¹,Jond Lionel¹,Mutero Annick¹,Chang Christopher J.²³,Citi Sandra¹

Affiliation:

1. Department of Cell Biology, Faculty of Sciences, University of Geneva, CH-1205 Geneva, Switzerland

2. Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720

3. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720

Abstract

The WW-PLEKHA proteins PLEKHA5, PLEKHA6, and PLEKHA7 coordinate together with PDZD11 the anterograde traffic of the copper pump ATP7A from the trans-Golgi network to the cell periphery. WW-PLEKHAs promote PDZD11 interaction with the C-terminus of ATP7A and are required for maintaining low intracellular copper levels when cells face elevated copper.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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