p52Shc regulates the sustainability of ERK activation in a RAF-independent manner-Reference-Cited by-同舟云学术

p52Shc regulates the sustainability of ERK activation in a RAF-independent manner

Published:2021-09-01 Issue:19 Volume:32 Page:1838-1848
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Yoshizawa Ryo¹²,Umeki Nobuhisa¹,Yamamoto Akihiro¹,Okada Mariko³⁴,Murata Masayuki²,Sako Yasushi¹

Affiliation:

1. Cellular Informatics Lab, RIKEN, Wako, Saitama 351-0198, Japan

2. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro, Tokyo 153-8902, Japan

3. Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan

4. Center for Drug Design and Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki 567-0085, Japan

Abstract

SHC and GRB2 transduce ERBB signals to the cytoplasm. Unexpectedly, these proteins show distinct translocation dynamics. Sustained SHC dynamics induces sustained ERK activation via a pathway from PI3K to MEK.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference64 articles.

1. The involvement of the docking protein Gab1 in mitogenic signalling induced by EGF and HGF in rat hepatocytes

2. Feedback inhibition by RALT controls signal output by the ErbB network

3. Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin

4. Feedback regulation of EGFR signalling: decision making by early and delayed loops

5. Intracellular signalling: PDK1 – a kinase at the hub of things

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bilateral regulation of EGFR activity and local PI dynamics observed with superresolution microscopy;2024-02-01

2. Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements;2023-08-07

3. Assessing transfer entropy from biochemical data;Physical Review E;2022-03-08