Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells-Reference-Cited by-同舟云学术

Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells

Published:2021-07-01 Issue:14 Volume:32 Page:1273-1282
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Knoblach Barbara¹,Ishida Ray²,Hobman Tom C.¹²³,Rachubinski Richard A.¹

Affiliation:

1. Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada

2. Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada

3. Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada

Abstract

Peroxisomes are central to mounting an antiviral response. We show that infection of cells by SARS-CoV-2 compromises peroxisome structure and matrix protein content. Inactivation of peroxisome-mediated antiviral signaling by disruption of peroxisomes may be a key strategy by which SARS-CoV-2 circumvents a primary defense mechanism against it.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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1. Antibodies directed against a yeast carboxyl-terminal peroxisomal targeting signal specifically recognize peroxisomal proteins from various yeasts

2. Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

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4. Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus

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