Plectin linkages are mechanosensitive and required for the nuclear piston mechanism of three-dimensional cell migration-Reference-Cited by-同舟云学术

Plectin linkages are mechanosensitive and required for the nuclear piston mechanism of three-dimensional cell migration

Published:2022-10-01 Issue:12 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Marks Pragati C.¹,Hewitt Breanne R.¹,Baird Michelle A.²,Wiche Gerhard³,Petrie Ryan J.¹

Affiliation:

1. Department of Biology, Drexel University, Philadelphia, PA 19104

2. Cell and Developmental Biology Center, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892

3. Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria

Abstract

The nucleus can hinder cell migration through three-dimensional environments due to its size and rigidity. We find that plectin cross-links vimentin and actomyosin filaments in response to substrate rigidity and these cross-links help to pull the nucleus forward in cells moving through the narrow openings in extracellular matrices.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference42 articles.

1. Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment

2. Not just scaffolding: plectin regulates actin dynamics in cultured cells

3. Of Cell Shapes and Motion: The Physical Basis of Animal Cell Migration

4. Keeping the Vimentin Network under Control: Cell–Matrix Adhesion–associated Plectin 1f Affects Cell Shape and Polarity of Fibroblasts

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