Analysis of senescence-responsive stress fiber proteome reveals reorganization of stress fibers mediated by elongation factor eEF2 in HFF-1 cells-Reference-Cited by-同舟云学术

Analysis of senescence-responsive stress fiber proteome reveals reorganization of stress fibers mediated by elongation factor eEF2 in HFF-1 cells

Published:2022-01-01 Issue:1 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Liu Shiyou¹,Matsui Tsubasa S.¹,Kang Na¹,Deguchi Shinji¹

Affiliation:

1. Division of Bioengineering, Graduate School of Engineering Science, Osaka University, Osaka 560-8531, Japan

Abstract

We identified with proteomic analysis the whole protein components of stress fibers (SFs) and how they change with cellular senescence. We demonstrated that eEF2 (eukaryotic translation elongation factor 2) is critical to the senescence-driven reorganization of SFs, providing a novel molecular basis for SFs to be reinforced to resist senescence.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference51 articles.

1. Repression of eEF2K transcription by NF-κB tunes translation elongation to inflammation and dsDNA-sensing

2. The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

3. The tension mounts: Stress fibers as force-generating mechanotransducers

4. Mechanotransduction at Cell-Matrix and Cell-Cell Contacts

5. Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Plasma cell-free RNA signatures of inflammatory syndromes in children;Proceedings of the National Academy of Sciences;2024-09-06

2. TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation;Respiratory Research;2024-08-07

3. Diffusion model predicts the geometry of actin cytoskeleton from cell morphology;PLOS Computational Biology;2024-08-05

4. Intracellular Macromolecular Crowding within Individual Stress Fibers Analyzed by Fluorescence Correlation Spectroscopy;Cellular and Molecular Bioengineering;2024-06

5. Plasma Cell-free RNA Signatures of Inflammatory Syndromes in Children;2024-03-08