SUMO paralogue–specific functions revealed through systematic analysis of human knockout cell lines and gene expression data-Reference-Cited by-同舟云学术

SUMO paralogue–specific functions revealed through systematic analysis of human knockout cell lines and gene expression data

Published:2021-09-01 Issue:19 Volume:32 Page:1849-1866
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Bouchard Danielle¹,Wang Wei¹,Yang Wei-Chih¹,He Shuying¹,Garcia Anthony¹,Matunis Michael J.¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205

Abstract

Analysis of SUMO1 and SUMO2 knockout cells reveals unique functions for SUMO paralogues in regulating cellular morphology, PML nuclear body structure, responses to proteotoxic and genotoxic stress, and control of gene expression. Findings reveal nonredundant regulatory roles for SUMO1 and SUMO2 and a basis for more precise SUMO-targeting therapies.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference108 articles.

1. How Does SUMO Participate in Spindle Organization?

2. SUMO proteins: Guardians of immune system

3. SUMO1 Haploinsufficiency Leads to Cleft Lip and Palate

4. Emerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septins

5. SUMOylation: re-wiring the plant nucleus during stress and development

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. SUMOylation at the crossroads of gut health: insights into physiology and pathology;Cell Communication and Signaling;2024-08-19

2. Central role of SUMOylation in the regulation of chromatin interactions and transcriptional outputs of the androgen receptor in prostate cancer cells;Nucleic Acids Research;2024-08-06

3. Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression;Cellular and Molecular Life Sciences;2024-04-08

4. Protein Stability Regulation in Osteosarcoma: The Ubiquitin-like Modifications and Glycosylation as Mediators of Tumor Growth and as Targets for Therapy;Cells;2024-03-18

5. SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer;Cell Reports;2024-03