Endosomal cargo recycling mediated by Gpa1 and phosphatidylinositol 3-kinase is inhibited by glucose starvation-Reference-Cited by-同舟云学术

Endosomal cargo recycling mediated by Gpa1 and phosphatidylinositol 3-kinase is inhibited by glucose starvation

Published:2022-04-01 Issue:4 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Laidlaw Kamilla M. E.¹,Paine Katherine M.¹,Bisinski Daniel D.¹,Calder Grant²,Hogg Karen²,Ahmed Sophia²,James Sally²,O’Toole Peter J.²,MacDonald Chris¹

Affiliation:

1. York Biomedical Research Institute and Department of Biology and

2. Bioscience Technology Facility, Department of Biology, University of York, YO10 5DD York, UK

Abstract

It is shown that glucose starvation elevates the Gα subunit Gpa2, which inhibits PI3K activity and endosomal recycling. Increased Gpa2 binds the PI3K effector Gpa1 at the surface, perturbing endosomal PtdIns3P production and inhibiting cargo recycling. Inhibition of recycling promotes cargo degradation in response to glucose starvation.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference113 articles.

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