Discovery of bactericides as an acute mitochondrial membrane damage inducer-Reference-Cited by-同舟云学术

Discovery of bactericides as an acute mitochondrial membrane damage inducer

Published:2021-11-01 Issue:21 Volume:32 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Houston Ryan¹,Sekine Yusuke¹²,Larsen Mads B¹,Murakami Kei³,Mullett Steven J.⁴,Wendell Stacy G.⁴,Narendra Derek P.⁵,Chen Bill B.¹⁶⁷,Sekine Shiori¹⁸

Affiliation:

1. Aging Institute, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219

2. Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219

3. Department of Chemistry, School of Science, Kwansei Gakuin University, Sanda, Hyogo, Japan

4. Department of Pharmacology and Chemical Biology, the Health Sciences Metabolomics and Lipidomics Core, University of Pittsburgh, Pittsburgh, PA 15261

5. Inherited Movement Disorders Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892

6. Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213

7. Vascular Medicine Institute, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261

8. Division of Cardiology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261

Abstract

Discovery of alexidine and chlorhexidine as small molecules to acutely and preferentially perturb the mitochondrial membrane architecture in the inner mitochondrial membrane, providing a unique chemical-biological tool for delineating mitochondrial membrane stress responses.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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