The [PSI+] prion modulates cytochrome c oxidase deficiency caused by deletion of COX12-Reference-Cited by-同舟云学术

The [PSI⁺] prion modulates cytochrome c oxidase deficiency caused by deletion of COX12

Published:2022-12-01 Issue:14 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Saini Pawan Kumar¹,Dawitz Hannah²,Aufschnaiter Andreas²,Bondarev Stanislav³,Thomas Jinsu¹,Amblard Amélie¹,Stewart James⁴⁵,Thierry-Mieg Nicolas¹,Ott Martin²⁶,Pierrel Fabien¹^ORCID

Affiliation:

1. Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France

2. Department of Biochemistry and Biophysics, Stockholm University, Stockholm 10691, Sweden

3. Department of Genetics and Biotechnology, St. Petersburg State University, St. Petersburg, Russia

4. Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931 Cologne, Germany

5. Wellcome Centre for Mitochondrial Research, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom

6. Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg 40530, Sweden

Abstract

Yeast cells lacking the Cox12 subunit of Cytochrome c (CcO) oxidase are impaired in mitochondrial respiration. With a combination of experimental evolution, genetics, and biochemistry, we prove that elimination of the PSI+ prion improves CcO oxidase activity and respiratory metabolism in strains lacking Cox12.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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