Endoplasmic reticulum–to–Golgi trafficking of procollagen III via conventional vesicular and tubular carriers

Abstract

Collagen is the major protein component of the extracellular matrix, consisting of three α chains that form a triple helix 300-400 nm in length. Live-cell imaging revealed that fibril-forming procollagen III was transported to the Golgi apparatus by conventional vesicular and tubular cargo carriers, requiring SAR1, TANGO1, and CUL3 for ER exit.