Nir1 constitutively localizes at ER–PM junctions and promotes Nir2 recruitment for PIP<sub>2</sub> homeostasis-Reference-Cited by-同舟云学术

Nir1 constitutively localizes at ER–PM junctions and promotes Nir2 recruitment for PIP₂ homeostasis

Published:2022-03-01 Issue:3 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Quintanilla Carlo Giovanni¹,Lee Wan-Ru¹,Liou Jen¹

Affiliation:

1. Department of Physiology, UT Southwestern Medical Center, TX 75390

Abstract

Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP2) homeostasis in stimulated cells is mediated by recruiting the lipid transfer protein Nir2 to endoplasmic reticulum (ER)–PM junctions. In this article, Nir1 is identified as a novel ER–PM junction localized protein that promotes Nir2 recruitment for PIP2 homeostasis.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference39 articles.

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2. Differential Regulation of Endoplasmic Reticulum Structure through VAP-Nir Protein Interaction

3. AUTOIMMUNE RETINOPATHY IN A PATIENT WITH A MISSENSE MUTATION IN PITPNM3

4. Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

5. DISTRIBUTION AND PROPERTIES OF CDP-DIGLYCERIDE:INOSITOL TRANSFERASE FROM BRAIN

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