Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1-Reference-Cited by-同舟云学术

Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1

Published:2022-06-01 Issue:7 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Powers Regina M.¹²,Daza Ray²³,Koehler Alanna E.²³,Courchet Julien⁴,Calabrese Barbara¹²,Hevner Robert F.²³,Halpain Shelley¹²

Affiliation:

1. Department of Neurobiology, University of California, San Diego, La Jolla, CA 92093

2. Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037

3. Department of Pathology, University of California, San Diego, La Jolla, CA 92161

4. Institut NeuroMyoGène, CNRS UMR5310, INSERM U1217, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon I, 69008 Lyon Cedex, France

Abstract

Neuron navigator 1 promotes F-actin membrane ruffles in the neuronal growth cone and promotes macropinocytosis at the membrane ruffles. This process includes uptake of the neurotrophin TrkB in growth cones, suggesting a novel mechanism for regulation of neuritogenesis by neuron Nav1.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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