Large-scale mapping of positional changes of hypoxia-responsive genes upon activation-Reference-Cited by-同舟云学术

Large-scale mapping of positional changes of hypoxia-responsive genes upon activation

Published:2022-07-01 Issue:8 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Nakayama Koh¹²³,Shachar Sigal³,Finn Elizabeth H.³,Sato Hiroyuki⁴,Hirakawa Akihiro⁴,Misteli Tom³

Affiliation:

1. Oxygen Biology Laboratory, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo 113-8510, Japan

2. Department of Pharmacology, School of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan

3. Cell Biology of Genomes Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

4. Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo 113-8510, Japan

Abstract

A high-throughput imaging platform was used to perform a large-scale analysis of the spatial location of hypoxia-responsive genes. The location of some genes changed upon hypoxia; however, they did not correlate with the extent of their activation, indicating that gene positions and expression are not strictly linked in hypoxic gene activation.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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