Regulation of apical constriction via microtubule- and Rab11-dependent apical transport during tissue invagination

Abstract

During tissue invagination, contractile actomyosin structures generate the cellular forces that drive apical constriction. Using the Drosophila embryonic salivary gland as a model for epithelial tube formation, we show that microtubule- and Rab11-dependent apical transport is critical for regulating actomyosin networks during invagination.