TAK1 is essential for endothelial barrier maintenance and repair after lung vascular injury-Reference-Cited by-同舟云学术

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TAK1 is essential for endothelial barrier maintenance and repair after lung vascular injury

Published:2022-06-01 Issue:7 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Wang Dong-Mei¹,Soni Dheeraj¹,Regmi Sushil C.¹,Vogel Stephen M.¹,Tiruppathi Chinnaswamy¹

Affiliation:

1. Department of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois, Chicago, IL 60612

Abstract

TGF-β-activated kinase 1 (TAK1) inhibition or ablation of TAK1 expression in adult mice endothelial cells caused endothelial barrier breakdown due to loss of β-catenin expression. Mechanistically, TAK1 inactivates GSK3β through AKT activation which in turn stabilizes the endothelial barrier.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference49 articles.

1. β-catenin is a target for the ubiquitin–proteasome pathway

2. Ubiquitin-mediated activation of TAK1 and IKK

3. TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils

4. Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

5. The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. TAK1 in Vascular Signaling: “Friend or Foe”?;Journal of Inflammation Research;2024-05

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