Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

Abstract

Chemoattractants induce a fast cGMP response in Dictyostelium. The cGMP signaling pathway consists of a soluble guanylyl cyclase sGC, a cGMP-stimulated PDE, and the cGMP-target protein GbpC. Here we combine published and many unpublished experiments performed in the past 45 years on the regulation and function of the cGMP signaling pathway.