Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating-Reference-Cited by-同舟云学术

Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating

Published:2021-10-01 Issue:20 Volume:32 Page:ar12
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Saito Hiroko¹,Matsukawa-Usami Fumiko²,Fujimori Toshihiko²,Kimura Toshiya¹,Ide Takahiro³,Yamamoto Takaki⁴,Shibata Tatsuo⁵,Onoue Kenta⁶,Okayama Satoko⁶,Yonemura Shigenobu⁶,Misaki Kazuyo⁷,Soba Yurina⁸,Kakui Yasutaka⁸⁹,Sato Masamitsu⁸,Toya Mika¹⁸¹⁰,Takeichi Masatoshi¹

Affiliation:

1. Laboratory for Cell Adhesion and Tissue Patterning

2. Division of Embryology, National Institute for Basic Biology, and Department of Basic Biology, School of Life Science, SOKENDAI, the Graduate University for Advanced Studies, Okazaki, 444-8787 Japan

3. Laboratory for Organismal Patterning

4. Nonequilibrium Physics of Living Matter RIKEN Hakubi Research Team

5. Laboratory for Physical Biology, and

6. Ultrastructural Research Team, RIKEN Center for Life Science Technologies, Kobe 650-0047, Japan

7. Laboratory for Ultrastructural Research, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan

8. Laboratory of Cytoskeletal Logistics, Center for Advanced Biomedical Sciences (TWIns), Waseda University, Tokyo 162-8480, Japan

9. Waseda Institute for Advanced Study, Waseda University, Tokyo 169-0051, Japan

10. Major in Bioscience, Global Center for Science and Engineering, Faculty of Science and Engineering, Waseda University, Tokyo 169-8555, Japan

Abstract

CAMSAP3, a protein that controls microtubule dynamics by binding to its minus-end, is localized at proximal regions of the axoneme in tracheal motile cilia. Its dysfunction results in a collapse of the central microtube pair, basal plate disorganization, and uncoordinated beating of multicilia.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference64 articles.

1. The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins

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3. Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells

4. Multiciliated Cells

5. Characterizing the ultrastructure of primary ciliary dyskinesia transposition defect using electron tomography

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