A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding-Reference-Cited by-同舟云学术

A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding

Published:2021-08-19 Issue:18 Volume:32 Page:1677-1689
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Barrick Samantha K.¹,Greenberg Lina¹,Greenberg Michael J.¹

Affiliation:

1. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110

Abstract

A variant in troponin T associated with dilated cardiomyopathy, R134G, decouples thin filament activation from calcium and myosin binding. These defects lead to molecular and cellular hypocontractility and sarcomeric disorganization in cardiomyocytes, demonstrating that altered molecular forces drive the disease pathogenesis.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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