Ovarian carcinoma immunoreactive antigen–like protein 2 (OCIAD2) is a novel complex III–specific assembly factor in mitochondria

Author:

Chojnacka Katarzyna Justyna1,Elancheliyan Praveenraj2,Mussulini Ben Hur Marins2,Mohanraj Karthik2,Callegari Sylvie34,Gosk Aleksandra1,Banach Tomasz2,Góral Tomasz1,Szczepanowska Karolina2,Rehling Peter456,Serwa Remigiusz Adam2,Chacinska Agnieszka2

Affiliation:

1. Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland

2. ReMedy International Research Agenda Unit, International Institute of Molecular Mechanisms and Machines (IMol), Polish Academy of Sciences, 00-783 Warsaw, Poland

3. Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia

4. Department of Cellular Biochemistry, University Medical Center Göttingen, 37073 Göttingen, Germany

5. Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Goettingen, 37075 Göttingen, Germany

6. Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany

Abstract

Using a combination of techniques (mass spectrometry, BN–PAGE, immunodetection, and mitochondrial in vitro import assays), it is reported that a previously poorly described protein, OCIAD2, localizes to the inner mitochondrial membrane and participates in the formation of electron transport chain complexes.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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