Acetate regulates GAPDH acetylation and T helper 1 cell differentiation

Abstract

The metabolite acetyl-CoA has emerged as a major signal transducer that can affect cell fate and function by influencing acetylation of key proteins. The mechanism by which acetyl-CoA regulates CD4+ T-cell fate determination remains poorly understood. Herein, it is reported that acetate modulates GAPDH acetylation and CD4+ T helper 1 cell differentiation by altering acetyl-CoA levels.