p97/VCP drives turnover of SUMOylated centromeric CCAN proteins and CENP-A-Reference-Cited by-同舟云学术

p97/VCP drives turnover of SUMOylated centromeric CCAN proteins and CENP-A

Published:2023-05-01 Issue:5 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

van den Berg Sebastiaan J. W.¹²,East Samuel¹,Mitra Sreyoshi¹,Jansen Lars E. T.¹

Affiliation:

1. Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK

2. Instituto Gulbenkian de Ciencia, 2780-156 Oeiras, Portugal

Abstract

We show that centromeric chromatin size is maintained by a dynamic SUMO cycle driving centromeric protein turnover by the p97 segregase, which is opposed by the deSUMOylase SENP6, ensuring proper centromere and kinetochore function.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference52 articles.

1. HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

2. Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51–Rad52 interaction

3. Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy

4. Analysis of Protein Turnover by Quantitative SNAP-Based Pulse-Chase Imaging

5. Assembly in G1 phase and long-term stability are unique intrinsic features of CENP-A nucleosomes

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