Regulation of neurofilament length and transport by a dynamic cycle of phospho-dependent polymer severing and annealing-Reference-Cited by-同舟云学术

Regulation of neurofilament length and transport by a dynamic cycle of phospho-dependent polymer severing and annealing

Published:2023-06-01 Issue:7 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Uchida Atsuko¹^ORCID,Peng Juan²,Brown Anthony¹^ORCID

Affiliation:

1. Department of Neuroscience, Ohio State University, Columbus, OH 43210

2. Center for Biostatistics and Department of Biomedical Informatics, Ohio State University, Columbus, OH 43210

Abstract

It is demonstrated that neurofilament length and transport are regulated by a dynamic cycle of neurofilament polymer severing and end-to-end annealing. An enzymatic severing mechanism for neurofilaments involving N-terminal phosphorylation of their constituent polypeptides is proposed.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference83 articles.

1. Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments

2. Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure

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4. Identification of Phosphorylation Sites on Neurofilament Proteins by Nanoelectrospray Mass Spectrometry

5. Interval between the synthesis and assembly of cytoskeletal proteins in cultured neurons

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