The short-chain fatty acid acetate coordinates with CD30 to modulate T-cell survival-Reference-Cited by-同舟云学术

The short-chain fatty acid acetate coordinates with CD30 to modulate T-cell survival

Published:2023-07-01 Issue:8 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Lyu Junfang¹²,Li Ziyi³,Roberts Jessica P.³,Qi Yue A.³,Xiong Jianhua¹²

Affiliation:

1. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, St. Petersburg, FL 33701

2. Institute for Fundamental Biomedical Research, Johns Hopkins All Children’s Hospital, St. Petersburg, FL 33701

3. Center for Alzheimer’s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892

Abstract

As an important substrate for cell metabolism, the short-chain fatty acid acetate emerges as a regulator of cell fate and function. Our results demonstrate that acetate is a metabolic regulator of T-cell survival by regulating levels of acetylated α-tubulin, which suggests that therapeutic manipulation of acetate metabolism may facilitate optimal T-cell responses under pathological conditions.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference43 articles.

1. Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation

2. Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

3. Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

4. The spectrum of T cell metabolism in health and disease

5. Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

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