Molecular Mechanism of Cell-autonomous Circadian Gene Expression of Period2, a Crucial Regulator of the Mammalian Circadian Clock-Reference-Cited by-同舟云学术

Molecular Mechanism of Cell-autonomous Circadian Gene Expression of Period2, a Crucial Regulator of the Mammalian Circadian Clock

Published:2006-02 Issue:2 Volume:17 Page:555-565
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Akashi Makoto¹,Ichise Tomoko¹,Mamine Takayoshi²,Takumi Toru¹

Affiliation:

1. Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan

2. Life Science Laboratory, Material Laboratories, Sony, Shinagawa, Tokyo 144-0001, Japan

Abstract

Although circadian transcription of Period2 (Per2) is fundamental for the generation of circadian rhythm, the molecular mechanism remains unclear. Here we report that cell-autonomous circadian transcription of Per2 is driven by two transcriptional elements, one for rhythm generation and the other for phase control. The former contains the E-box-like sequence (CACGTT) that is sufficient and indispensable to drive oscillation, and indeed circadian transcription factors site-specifically bind to it. Furthermore, the nature of this atypical E-box is different from that of the classical circadian E-box. The current feedback loop model is based mainly on Period1. Our results provide not only compelling evidence in support of this model but also an explanation for a general basic mechanism to produce various patterns in the phase and amplitude of cell-autonomous circadian gene expression.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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