Molecular Mechanism of Cell-autonomous Circadian Gene Expression of Period2, a Crucial Regulator of the Mammalian Circadian Clock-Reference-Cited by-同舟云学术

Molecular Mechanism of Cell-autonomous Circadian Gene Expression of Period2, a Crucial Regulator of the Mammalian Circadian Clock

Published:2006-02 Issue:2 Volume:17 Page:555-565
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Akashi Makoto¹,Ichise Tomoko¹,Mamine Takayoshi²,Takumi Toru¹

Affiliation:

1. Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan

2. Life Science Laboratory, Material Laboratories, Sony, Shinagawa, Tokyo 144-0001, Japan

Abstract

Although circadian transcription of Period2 (Per2) is fundamental for the generation of circadian rhythm, the molecular mechanism remains unclear. Here we report that cell-autonomous circadian transcription of Per2 is driven by two transcriptional elements, one for rhythm generation and the other for phase control. The former contains the E-box-like sequence (CACGTT) that is sufficient and indispensable to drive oscillation, and indeed circadian transcription factors site-specifically bind to it. Furthermore, the nature of this atypical E-box is different from that of the classical circadian E-box. The current feedback loop model is based mainly on Period1. Our results provide not only compelling evidence in support of this model but also an explanation for a general basic mechanism to produce various patterns in the phase and amplitude of cell-autonomous circadian gene expression.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference45 articles.

1. Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., and Block, G. D. (2002). Circadian rhythms in isolated brain regions. J. Neurosci. 22, 350-356.

2. Akashi, M., and Nishida, E. (2000). Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock. Genes Dev. 14, 645-649.

3. Akashi, M., and Takumi, T. (2005). The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1. Nat. Struct. Mol. Biol. 12, 441-448.

4. Akashi, M., Tsuchiya, Y., Yoshino, T., and Nishida, E. (2002). Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells. Mol. Cell. Biol. 22, 1693-1703.

5. Albrecht, U., and Eichele, G. (2003). The mammalian circadian clock. Curr. Opin. Genet. Dev. 13, 271-277.

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