TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins-Reference-Cited by-同舟云学术

TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins

Published:2023-01-01 Issue:1 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Nguyen Abraham¹²^ORCID,Goetz Sarah C.²^ORCID

Affiliation:

1. Molecular Cancer Biology Program, Duke University School of Medicine, Durham, NC 27710

2. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710

Abstract

Tau tubulin kinase 2 (TTBK2) controls multiple aspects of cilia formation, including cilium assembly and cilia structural integrity. Here we use live imaging to follow the consequences of Ttbk2 loss in real time. We find that Ttbk2 maintains ciliary stability through actin and centriolar satellites and in parallel maintains basal body intraflagellar transport pools.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference49 articles.

1. Acute inhibition of centriolar satellite function and positioning reveals their functions at the primary cilium

2. Lineage specificity of primary cilia in the mouse embryo

3. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

4. TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons

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