Cell contractility drives mechanical memory of oral squamous cell carcinoma-Reference-Cited by-同舟云学术

Cell contractility drives mechanical memory of oral squamous cell carcinoma

Published:2023-08-01 Issue:9 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Moon So Youn¹²,de Campos Paloma Santos³,Matte Bibiana Franzen³,Placone Jesse K.¹⁴,Zanella Virgı´lio G.³⁵,Martins Manoela D.³,Lamers Marcelo Lazzaron³⁶,Engler Adam J.¹²

Affiliation:

1. Department of Bioengineering, University of California San Diego, La Jolla, CA 92093

2. Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037

3. Department of Oral Pathology, Federal University of Rio Grande do Sul

4. Department of Physics and Engineering, West Chester University of Pennsylvania, West Chester, PA 19383

5. Department of Head and Neck Surgery, Santa Rita Hospital, Santa Casa de Misericórdia de Porto, Alegre

6. Deparment of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS 90035, Brazil

Abstract

Oral cancer cells sense and respond to matrix stiffness via myosin contractility. As part of their response, they use AKT and FAK signaling to retain and recall the ‘memory’ developed within the tumor core to remain highly migratory and mesenchymal in tumor adjacent epithelium, despite being significantly softer.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference74 articles.

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3. Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

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