F-actin organization and target constriction during primary macrophage phagocytosis is balanced by competing activity of myosin-I and myosin-II-Reference-Cited by-同舟云学术

F-actin organization and target constriction during primary macrophage phagocytosis is balanced by competing activity of myosin-I and myosin-II

Published:2022-12-01 Issue:14 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Barger Sarah R.¹,Vorselen Daan²³,Gauthier Nils C.⁴,Theriot Julie A.²,Krendel Mira¹

Affiliation:

1. Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY 13210

2. Department of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195

3. Cell Biology and Immunology, Wageningen University and Research, Wageningen, the Netherlands

4. IFOM, FIRC Institute of Molecular Oncology, Milan, Italy

Abstract

Analysis of forces produced during phagocytosis of deformable targets by primary macrophages shows that phagocytic force production and actin distribution in these cells is determined by a balance between myosin-I and myosin-II activity.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference35 articles.

1. Squeezing in a Meal: Myosin Functions in Phagocytosis

2. Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis

3. Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target

4. The clearance of dead cells by efferocytosis

5. Harnessing and Enhancing Macrophage Phagocytosis for Cancer Therapy

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