Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis-Reference-Cited by-同舟云学术

Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis

Published:2022-12-01 Issue:14 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Poddar Abhishek¹,Hsu Yen-Yu²,Zhang Faith¹,Shamma Abeda³,Kreais Zachary³,Muller Clare¹,Malla Mamata¹,Ray Aniruddha³,Liu Allen P.²⁴⁵⁶,Chen Qian¹^ORCID

Affiliation:

1. Department of Biological Sciences, University of Toledo, Toledo, OH 43606

2. Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109

3. Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606

4. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109

5. Department of Biophysics, University of Michigan, Ann Arbor, MI 48109

6. Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109

Abstract

The fission yeast polycystin channel Pkd2 is required for the expansion of cell volume during cell growth and cytokinesis. Here, we discovered that Pkd2 is permeable to calcium when it is activated by membrane stretching, and this putative channel promotes separation calcium spikes during cytokinesis.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference53 articles.

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2. Isolation and Characterization of New Fission Yeast Cytokinesis Mutants

3. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans

4. Yeast Respond to Hypotonic Shock with a Calcium Pulse

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